Is it safe to take painkillers with prescribed medicine?

Check the prescription information pamphlet or search online.  Without telling us what the painkiller is and what the prescribed drug is, we can't tell you.

Always check with a pharmacist. Anon answered ''common drugs rarely combine to be dangerous'', which is nonsense 'advice' and could end up killing someone which is probably why they answered anonymously. I'm on a fairly common prescribed muscle relaxant but it reacts with almost every over the counter medication I try to buy from medication to treat a yeast infection to cough mixture resulting in severe heart problems. I also got mis-diagnosed with epilepsy at some point because 2 commonly prescribed medications interacted and gave me tonic clonic seizures and the doctor missed the interaction. 

I can take a look for the drug interactions for you online if you wish if you post the names of the meds and dosage but I did not complete my pharmacology degree and I am not a licensed medical professional.

Well genius, that depends on WHICH painkiller and WHICH prescribed meds.

Read the manual, or consult your doctor/pharmacist

just put both drug names into google and see what it spits out.

common drugs rarely combine to be dangerous but it does happen.

opiates are the worst culprits.

depends on the "prescribed tablet". Ask your pharmacist or doctor.

would you really trust advice from this forum, full of teenage trolls?